Perturbed gut microbiome and fecal and serum metabolomes are associated with chronic kidney disease severity.

ABSTRACT:

Background

Chronic kidney disease (CKD) is a severe public health problem associated with a disordered gut microbiome. However, the functional alterations of microbiota and their cross talk with metabolism pathways based on disease severity remain unclear.

Results

We performed metagenomics and untargeted metabolomics in a cohort of 68 patients with CKD of differing severities and 20 healthy controls to characterize the complex interplay between the gut microbiome and fecal and serum metabolites during CKD progression. We identified 26 microbial species that significantly changed in patients with CKD; 18 species changed as the disease progressed, and eight species changed only in a specific CKD group. These distinct changes in gut microbiota were accompanied by functional alt

SUBMITTER: Wang H 

PROVIDER: S-EPMC9827681 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature