A benchtop brain injury model using resected donor tissue from patients with Chiari malformation.

ABSTRACT: The use of live animal models for testing new therapies for brain and spinal cord repair is a controversial area. Live animal models have associated ethical issues and scientific concerns regarding the predictability of human responses. Alternative models that replicate the 3D architecture of the central nervous system have prompted the development of organotypic neural injury models. However, the lack of reliable means to access normal human neural tissue has driven reliance on pathological or post-mortem tissue which limits their biological utility. We have established a protocol to use donor cerebellar tonsillar tissue surgically resected from patients with Chiari malformation (cerebellar herniation towards the foramen magnum, with ectopic rather than diseased tissue) to develop an in v

SUBMITTER: Tickle JA 

PROVIDER: S-EPMC9827764 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature