Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson's disease.

ABSTRACT: Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson's disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclear. The aim of this study was to investigate the potential effects of multiple single nucleotide polymorphisms on brain imaging phenotype in Parkinson's disease. Forty-eight Parkinson's disease patients and 39 matched healthy controls underwent genotyping and 7T magnetic resonance imaging. A cognitive-weighted polygenic risk score model was designed, in which the effect sizes were determined individually for 36 single nucleotide polymorphisms. The correlations between polygenic risk score, neuroimaging features, and clinical data were analyzed. Furthermore, individual single nuc

SUBMITTER: Shen T 

PROVIDER: S-EPMC9827791 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature