Cortical thickness and its relationship to cognitive performance and metabolic control in adults with phenylketonuria.

ABSTRACT: Despite good control of phenylalanine (Phe) levels during childhood and adolescence, adults with phenylketonuria (PKU) often show abnormalities in the white matter of the brain, which have been associated with poorer cognitive performance. However, whether such a relationship exists with cortical gray matter is still unknown. Therefore, we investigated cortical thickness and surface area in adults with early-treated PKU and their relationship to cognitive functions and metabolic control. We included 30 adult patients with early-treated and metabolically well-controlled PKU (median age: 35.5 years) and 54 healthy controls (median age: 29.3 years). Surface-based morphometry was derived from T1-weighted magnetic resonance images using FreeSurfer, and general intelligence, executive functions,

SUBMITTER: Muri R 

PROVIDER: S-EPMC9827942 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature