The Path to UVCB Ecological Risk Assessment: Grappling with Substance Characterization.

ABSTRACT: Substances of unknown or variable composition, complex reaction products, and biological materials (UVCBs) pose a unique challenge to regulators and to product registrants, who are required to characterize their fate, exposure, hazard, and potential risks to human health and the environment. To address these challenges and ensure an efficient and fit-for-purpose process, it is proposed that the ecological risks of UVCBs be assessed following a tiered strategy. The development of this approach required exploring how substance composition ties into hazard and exposure information and determining the extent to which a UVCB needs to be characterized to ensure a robust risk assessment. The present study highlights the key aspects of this new method. It presents how a tiered substance characteri

SUBMITTER: Salvito D 

PROVIDER: S-EPMC9828001 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature