Renal effects of empagliflozin in patients hospitalized for acute heart failure: from the EMPULSE trial.

ABSTRACT:

Aim

The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin improved clinical outcomes in patients hospitalized for acute heart failure. In patients with chronic heart failure, SGLT2 inhibitors cause an early decline in estimated glomerular filtration rate (eGFR) followed by a slower eGFR decline over time than placebo. However, the effects of SGLT2 inhibitors on renal function during a hospital admission for acute heart failure remain largely unknown.

Methods and results

Between 1 and 5 days after a hospitalization for acute heart failure, 530 patients with an eGFR >20 ml/min/1.73 m² were randomized to 10 mg of empagliflozin or placebo and treated for 90 days. Renal function and electrolytes were measured at baseline, and after 15, 30 and 90 days. We e

SUBMITTER: Voors AA 

PROVIDER: S-EPMC9828037 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature