Roles of long noncoding RNAs and small extracellular vesicle-long noncoding RNAs in type 2 diabetes.

ABSTRACT: The prevalence of a high-energy diet and a sedentary lifestyle has increased the incidence of type 2 diabetes (T2D). T2D is a chronic disease characterized by high blood glucose levels and insulin resistance in peripheral tissues. The pathological mechanism of this disease is not fully clear. Accumulated evidence has shown that noncoding RNAs have an essential regulatory role in the progression of diabetes and its complications. The roles of small noncoding RNAs, such as miRNAs, in T2D, have been extensively investigated, while the function of long noncoding RNAs (lncRNAs) in T2D has been unstudied. It has been reported that lncRNAs in T2D play roles in the regulation of pancreatic function, peripheral glucose homeostasis and vascular inflammation. In addition, lncRNAs carried by small ext

SUBMITTER: Chang W 

PROVIDER: S-EPMC9828071 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature