A Risk Score to Detect Subclinical Rheumatoid Arthritis-Associated Interstitial Lung Disease.

ABSTRACT:

Objective

Patients at high risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) would benefit from being identified before the onset of respiratory symptoms; this can be done by screening patients with the use of chest high-resolution computed tomography (HRCT). Our objective was to develop and validate a risk score for patients who have subclinical RA-ILD.

Methods

Our study included a discovery population and a replication population from 2 prospective RA cohorts (ESPOIR and TRANSLATE2, respectively) without pulmonary symptoms who had received chest HRCT scans. All patients were genotyped for MUC5B rs35705950. After multiple logistic regression, a risk score based on independent risk factors for subclinical RA-ILD was developed in the discovery populat

SUBMITTER: Juge PA 

PROVIDER: S-EPMC9828082 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature