Harnessing Water to Enhance Quadrupolar NMR Spectroscopy and Imaging.

ABSTRACT: ¹⁷ O and ¹⁴ N are attractive targets for in vivo NMR spectroscopy and imaging, but low gyromagnetic ratios γ and fast spin relaxation complicate observations. This work explores indirect ways of detecting some of these sites with the help of proton-detected double resonance techniques. As standard coherence transfer methods are of limited use for such indirect detection, alternative routes for probing the quadrupolar spectra on ¹ H were tested. These centered on modulating the broadening effects imparted onto protons adjacent to the low-γ species through J couplings through either continuous wave or spin-echo double-resonance decoupling/recoupling sequences. As in all cases, the changes imparted by these double-resonance strategies were small due to the fas

SUBMITTER: Martinho RP 

PROVIDER: S-EPMC9828088 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature