Genetic and environmental etiology of drinking motives in college students.

ABSTRACT:

Background

Drinking motives are robust proximal predictors of alcohol use behaviors and may mediate distinct etiological pathways in the development of alcohol misuse. However, little is known about the genetic and environmental etiology of drinking motives themselves and their potential utility as endophenotypes.

Methods

Here, we leverage a longitudinal study of college students from diverse racial/ethnic backgrounds (phenotypic N = 9889, genotypic N = 4855) to investigate the temporal stability and demographic and environmental predictors of four types of drinking motives (enhancement, social, coping, and conformity). Using genome-wide association study (GWAS) and in silico tools, we characterize their associated genes and genetic variants (single nucleotide polymorphisms

SUBMITTER: Savage JE 

PROVIDER: S-EPMC9828131 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature