Basophil activation test has high reproducibility and is feasible in the clinical setting.

ABSTRACT:

Background

The basophil activation test (BAT) has high accuracy to diagnose peanut allergy and can reduce the need for oral food challenges (OFC); however, so far it has not been incorporated in clinical practice.

Methods

We assessed the reproducibility of BAT within the same laboratory and between two different laboratories and the feasibility of using BAT in the clinical setting.

Results

One hundred and two children being assessed for peanut allergy were tested on BAT (72 allergic, 30 sensitized tolerant). There was little internal variation (coefficient of variation <15%) in the BAT and a very strong correlation (R_s  > .95) between BAT performed across laboratories. The 2 BAT methods were strongly correlated but not interchangeable. In the cases of discr

SUBMITTER: Jaumdally H 

PROVIDER: S-EPMC9828203 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature