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Gene, virulence and related regulatory mechanisms in Cryptococcus gattii.

ABSTRACT: Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathogenic mechanism of C. gattii has not been fully identified. With the development of genomics and transcriptomics, the relationship among genes, regulatory mechanisms, virulence, and treatment is gradually being recognized. In this review, to better understand how C. gattii causes disease and to characterize hypervirulent C. gattii strains, we summarize the current understanding of C. gattii genotypes, phenotypes, virulence, and the regulatory mechanisms.

SUBMITTER: Huang Y

PROVIDER: S-EPMC9828318 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Gene, virulence and related regulatory mechanisms in Cryptococcus gattii.

Huang Yemei Y Zang Xuelei X Yang Chen C Deng Hengyu H Ma Xidong X Xie Mei M Zhou Meng M Song Jialin J Xue Xinying X

Acta biochimica et biophysica Sinica 20220501 5

Cryptococcus gattii is a kind of basidiomycetous yeast, which grows in human and animal hosts. C. gattii has four distinct genomes, VGI/AFLP4, VGII/AFLP6, VGIII/AFLP5, and VGIV/AFLP7. The virulence of C. gattii is closely associated with genotype and related stress-signaling pathways, but the pathogenic mechanism of C. gattii has not been fully identified. With the development of genomics and transcriptomics, the relationship among genes, regulato ...[more]

PMID: 35593469

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