Comprehensive analysis of complement-associated molecular features in hepatocellular carcinoma.

ABSTRACT: The complement cascade plays a "complementing" role in human immunity. However, the potential roles of complement system in impacting molecular and clinical features of hepatocellular carcinoma (HCC) remain unclear. In this study, eleven public datasets are analyzed to compare the complement status between normal and cancerous samples based on 18 classical complement-associated genes. The complement scores are constructed to quantify complement signatures of individual tumors. HCC patients in the The Cancer Genome Atlas (TCGA) cohort are focused to perform systematical analyses between complement status and immune infiltration, miRNA expression, DNA methylation, clinicopathological features, and drug response. The results show that the complement scores in normal tissues are dramatically h

SUBMITTER: Huang R 

PROVIDER: S-EPMC9828444 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature