Two Directing Groups Used for Metal Catalysed Meta-C-H Functionalisation Only Effect Ortho Electrophilic C-H Borylation.

ABSTRACT: Two templates used in meta-directed C-H functionalisation under metal catalysis do not direct meta-C-H borylation under electrophilic borylation conditions. Using BCl₃ only Lewis adduct formation with Lewis basic sites in the template is observed. While combining BBr₃ and the template containing an amide linker only led to amide directed ortho C-H borylation, with no pyridyl directed meta borylation. The amide directed borylation is selective for the ortho borylation of the aniline derived unit in the template, with no ortho borylation of the phenylacetyl ring - which would also form a six membered boracycle - observed. In the absence of other aromatics amide directed ortho borylation on to phenylacetyl rings can be ach

SUBMITTER: Iqbal SA 

PROVIDER: S-EPMC9828458 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature