Ontology highlight
ABSTRACT: Aim
To describe adults with (non-dialysis) chronic kidney disease (CKD) in nine public renal practice sites in the Australian state of Queensland.Methods
7,060 persons were recruited to a CKD Registry in May 2011 and until start of kidney replacement therapy (KRT), death without KRT or June 2018, for a median period of 3.4 years.Results
The cohort comprised 7,060 persons, 52% males, with a median age of 68 yr; 85% had CKD stages 3A to 5, 45.4% were diabetic, 24.6% had diabetic nephropathy, and 51.7% were obese. Younger persons mostly had glomerulonephritis or genetic renal disease, while older persons mostly had diabetic nephropathy, renovascular disease and multiple diagnoses. Proportions of specific renal diagnoses varied >2-fold across sites. Over the first year, eGFR fell in 24% but was stable or improved in 76%. Over follow up, 10% started KRT, at a median age of 62 yr, most with CKD stages 4 and 5 at consent, while 18.8% died without KRT, at a median age of 80 yr. Indigenous people were younger at consent and more often had diabetes and diabetic kidney disease and had higher incidence rates of KRT.Conclusion
The spectrum of characteristics in CKD patients in renal practices is much broader than represented by the minority who ultimately start KRT. Variation in CKD by causes, age, site and Indigenous status, the prevalence of obesity, relative stability of kidney function in many persons over the short term, and differences between those who KRT and die without KRT are all important to explore.
SUBMITTER: Hoy WE
PROVIDER: S-EPMC9828529 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Hoy Wendy E WE Wang Zaimin Z Zhang Jianzhen J Diwan Vishal V Cameron Anne A Venuthurupalli Sree K SK Fassett Robert G RG Chan Samuel S Healy Helen G HG Tan Ken-Soon KS Baer Richard R Mallett Andrew J AJ Gray Nicholas N Mantha Murty M Cherian Roy R Mutatiri Clyson C Madhan Krishan K Kan George G Mitchell Geoffrey G Hossain Shahadat S Wu Danielle D Han Thin T Kark Adrian A Titus Thomas T Ranganathan Dwarakanatan D Bonner Ann A Govindarajulu Sridevi S
Nephrology (Carlton, Vic.) 20221009 12
<h4>Aim</h4>To describe adults with (non-dialysis) chronic kidney disease (CKD) in nine public renal practice sites in the Australian state of Queensland.<h4>Methods</h4>7,060 persons were recruited to a CKD Registry in May 2011 and until start of kidney replacement therapy (KRT), death without KRT or June 2018, for a median period of 3.4 years.<h4>Results</h4>The cohort comprised 7,060 persons, 52% males, with a median age of 68 yr; 85% had CKD stages 3A to 5, 45.4% were diabetic, 24.6% had dia ...[more]