Reproductive health and hemostatic issues in women and girls with congenital factor VII deficiency: A systematic review.

ABSTRACT:

Background

Congenital factor VII (FVII) deficiency is an inherited bleeding disorder, with heterogenous bleeding symptoms. Women with FVII deficiency face hemostatic challenges during menstruation, ovulation, and childbirth. This systematic review evaluated prevalence and management of bleeding symptoms associated with gynecological and obstetric issues in women with FVII deficiency.

Methods

Databases (BIOSIS Previews, Current Contents Search, Embase, and MEDLINE) were searched for studies reporting FVII deficiency and gynecological or obstetric issues in women. Articles were screened using Joanna Briggs Institute checklists and relevant data extracted.

Results

One hundred fourteen women were identified from 62 publications. Forty-six women had severe deficiency (FVII

SUBMITTER: Abdul-Kadir R 

PROVIDER: S-EPMC9828586 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature