Epigenomic and somatic mutations of pituitary tumors with clinical and pathological correlations in 111 patients.

ABSTRACT:

Objective

To profile clinically non-aggressive and aggressive pituitary adenomas (PAs)/pituitary neuroendocrine tumours (PitNETs) and pituitary carcinomas for somatic mutations and epigenetic alterations of genes involved in cell proliferation/differentiation, microRNAs (miRNA)/long noncoding RNA (LncRNA)-post-transcriptional regulators and therapy targets.

Design

Retrospective observational study.

Patients and measurements

A total of 64 non-aggressive and 41 aggressive PAs/PitNETs and 6 pituitary carcinomas treated by endoscopic surgery with ≥1-year follow-up were included. Somatic mutations of 17 genes and DNA methylation of 22 genes were assessed. Ten normal pituitaries were used as control.

Results

We found at least one mutation in 17 tumours, including 6/6

SUBMITTER: Guaraldi F 

PROVIDER: S-EPMC9828656 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature