A high-dimensional cytometry atlas of peripheral blood over the human life span.

ABSTRACT: Age can profoundly affect susceptibility to a broad range of human diseases. Children are more susceptible to some infectious diseases such as diphtheria and pertussis, while in others, such as coronavirus disease 2019 and hepatitis A, they are more protected compared with adults. One explanation is that the composition of the immune system is a major contributing factor to disease susceptibility and severity. While most studies of the human immune system have focused on adults, how the immune system changes after birth remains poorly understood. Here, using high-dimensional spectral flow cytometry and computational methods for data integration, we analyzed more than 50 populations of immune cells in the peripheral blood, generating an immune cell atlas that defines the healthy human immun

SUBMITTER: Jalali S 

PROVIDER: S-EPMC9828744 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature