Heart failure outcomes according to heart rate and effects of empagliflozin in patients of the EMPEROR-Preserved trial.

ABSTRACT:

Aims

Empagliflozin reduces cardiovascular death (CVD) or heart failure hospitalization (HHF) in patients with heart failure and preserved ejection fraction (HFpEF). Treatment effects and safety in relation to resting heart rate (RHR) have not been studied.

Methods and results

The interplay of RHR and empagliflozin effects in EMPEROR-Preserved was evaluated. We grouped patients (n = 5988) according to their baseline RHR (<70 bpm [n = 2650], 70-75 bpm [n = 967], >75 bpm [n = 1736]) and explored the influence of RHR on CVD or HHF (primary outcome) and its components in sinus rhythm or atrial fibrillation/flutter (AF) and adverse events. We studied the efficacy of empagliflozin across the RHR spectrum. Compared to placebo, empagliflozin did not change heart rate over time. The p

SUBMITTER: Bohm M 

PROVIDER: S-EPMC9828798 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature