The vital role of arcuate nociceptin/orphanin FQ neurones in mounting an oestradiol-dependent adaptive response to negative energy balance via inhibition of nearby proopiomelanocortin neurones.

ABSTRACT: We tested the hypothesis that N/OFQ neurones in the arcuate nucleus (N/OFQ^ARC ) inhibit proopiomelanocortin (POMC^ARC ) neurones in a diet- and hormone-dependent manner to promote a more extensive rebound hyperphagia upon re-feeding following an 18 h fast. We utilized intact male or ovariectomized (OVX) female mice subjected to ad libitum-feeding or fasting conditions. N/OFQ^ARC neurones under negative energy balance conditions displayed heightened sensitivity as evidenced by a decreased rheobase threshold, increased firing frequency, and increased burst duration and frequency compared to ad libitum-feeding conditions. Stimulation of N/OFQ^ARC neurones more robustly inhibited POMC^ARC neurones under fasting conditions compared to ad libitu

SUBMITTER: Sayers S 

PROVIDER: S-EPMC9828807 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature