Synthesis and antimicrobial activity of aminoalkyl resveratrol derivatives inspired by cationic peptides.

ABSTRACT: Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. In this work, we present a family of aminoalkyl resveratrol derivatives with antibacterial activity inspired by the properties of cationic amphipathic antimicrobial peptides. Surprisingly, the newly designed molecules display modest activity against aerobically growing bacteria but show surprisingly good antimicrobial activity against anaerobic bacteria (Gram-negative and Gram-positive) suggesting specificity towards this bacterial group. Preliminary studies into the action mechanism suggest that activity takes place at the membrane level, while no cross-resistance with traditional antibiotics is observed. Actually, some good synergistic relations with existing anti

SUBMITTER: Cebrian R 

PROVIDER: S-EPMC9828810 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature