The effects of B-cell-activating factor on the population size, maturation and function of murine natural killer cells.

ABSTRACT: The role of B-cell-activating factor (BAFF) in B-lymphocyte biology has been comprehensively studied, but its contributions to innate immunity remain unclear. Natural killer (NK) cells form the first line of defense against viruses and tumors, and have been shown to be defective in patients with systemic lupus erythematosus (SLE). The link between BAFF and NK cells in the development and progression of SLE remains unstudied. By assessing NK cell numbers in wild-type (WT), BAFF^-/- (BAFF deficient), BAFF-R^-/- (BAFF receptor deficient), TACI^-/- (transmembrane activator and calcium modulator and cyclophilin ligand interactor deficient), BCMA^-/- (B-cell maturation antigen deficient) and BAFF transgenic (Tg) mice, we observed that BAFF signaling throug

SUBMITTER: Quah PS 

PROVIDER: S-EPMC9828838 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature