Time of coronary revascularization: methodology of a mediation analysis study.

ABSTRACT:

Background

The advantage of coronary artery bypass grafting (CABG) over percutaneous coronary intervention (PCI), established in trials, may not be generalizable to populations in which the method of treatment determines the time to treatment. We sought to describe the methodology of a population-based observational study for assessing how changes in time to treatment may affect the comparative effectiveness of these 2 methods of coronary revascularization.

Methods

We propose a framework of causal mediation analysis to compare the outcomes of choosing CABG over PCI, if patients selected for either method waited the same amount of time had they undergone a PCI. We will include patients who underwent a first-time, nonurgent isolated CABG or single-session PCI for multivessel o

SUBMITTER: Sobolev B 

PROVIDER: S-EPMC9828946 | biostudies-literature | 2022 Oct-Dec

REPOSITORIES: biostudies-literature