TXNIP Suppresses the Osteochondrogenic Switch of Vascular Smooth Muscle Cells in Atherosclerosis.

ABSTRACT:

Background

The osteochondrogenic switch of vascular smooth muscle cells (VSMCs) is a pivotal cellular process in atherosclerotic calcification. However, the exact molecular mechanism of the osteochondrogenic transition of VSMCs remains to be elucidated. Here, we explore the regulatory role of TXNIP (thioredoxin-interacting protein) in the phenotypical transitioning of VSMCs toward osteochondrogenic cells responsible for atherosclerotic calcification.

Methods

The atherosclerotic phenotypes of Txnip^-/- mice were analyzed in combination with single-cell RNA-sequencing. The atherosclerotic phenotypes of Tagln-Cre; Txnip^flox/flox mice (smooth muscle cell-specific Txnip ablation model), and the mice transplanted with the bone marro

SUBMITTER: Woo SH 

PROVIDER: S-EPMC9829043 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature