Metformin use and associated risk of total joint replacement in patients with type 2 diabetes: a population-based matched cohort study.

ABSTRACT:

Background

It is uncertain whether metformin use is associated with reduced risk of joint replacement in patients with type 2 diabetes mellitus. We aimed to establish whether metformin use was associated with a reduced risk of total knee replacement (TKR) or total hip replacement (THR) among these patients.

Methods

We selected patients with type 2 diabetes mellitus that was diagnosed between 2000 and 2012 from the Taiwan National Health Insurance Research Database. We used prescription time-distribution matching and propensity-score matching to balance potential confounders between metformin users and nonusers. We assessed the risks of TKR or THR using Cox proportional hazards regression.

Results

We included 20 347 participants who were not treated with metformin and

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC9829054 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature