Association of vitamin D receptor polymorphisms with colorectal cancer susceptibility: A systematic meta-analysis.

ABSTRACT:

Background

Recent studies have reported an association between vitamin D receptor (VDR) polymorphisms and colorectal cancer (CRC) risk; however, the results are controversial. This meta-analysis was performed to investigate whether the Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms were correlated with CRC susceptibility.

Methods

All potential studies were retrieved by searching the PubMed, EMBASE, and Cochrane Library databases through October 2, 2021. Odds ratios (ORs) with 95% confidence intervals were used to evaluate the correlation between VDR gene Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI polymorphisms and CRC risk.

Results

In this meta-analysis, the BsmI variant was significantly correlated with a lower risk of CRC, especially in Caucasian population (B

SUBMITTER: Yang M 

PROVIDER: S-EPMC9829264 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature