Use of Aerosolized Prostacyclins in Critically Ill Patients and Association With Clinical Outcomes.

ABSTRACT: Aerosolized prostacyclins are frequently used in patients with severe acute respiratory distress syndrome and refractory hypoxia. Previous studies have shown improvement in oxygenation with use of pulmonary vasodilators such as iloprost and epoprostenol; however, there is no head-to-head comparison between these agents.

Objectives

To compare the effects of inhaled epoprostenol and inhaled iloprost in critically ill patients with refractory hypoxia.

Design setting and participants

We performed a retrospective cohort analysis of patients admitted to the ICUs at the University of Oklahoma Health Sciences Center between 2015 and 2018. Adult patients who received aerosolized epoprostenol or iloprost for more than 4 hours were included in the analysis.

Main outcomes and measures

SUBMITTER: Hussain ST 

PROVIDER: S-EPMC9829278 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature