Phylogenetic analysis of all available monkeypox virus strains shows the close relatedness of contemporary ones.

ABSTRACT: The present research aimed to evaluate the diversity of all monkeypox virus strains with a special focus on recently isolated ones by a comprehensive phylogenetic analysis of all available sequences, based on the concatenate of four viral genes. Almost all current strains from 2022 showed a high level of similarity to each other on the analyzed stretches: 218 strains shared identical sequence. Among all analyzed strains, the highest number of differences was counted compared to a RefSeq strain (Zaire-96-I-16) on the whole concatenate. Our analysis supported the distinction between Clade I (formerly Congo Basin clade), IIa and IIb (together formerly West African clade) strains and classified all 2022 strains in the last one. The high number of differences and long branch observable concerni

SUBMITTER: Benko M 

PROVIDER: S-EPMC9829444 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature