The potential public health impact of adolescent 4CMenB vaccination on Neisseria gonorrhoeae infection in England: a modelling study.

ABSTRACT:

Introduction

Diagnoses of gonorrhoea in England rose by 26% between 2018 and 2019. Recent evidence that a vaccine against meningococcal B disease currently offered to infants in the UK (4CMenB) could additionally protect (with 31% efficacy) against gonorrhoea has led to renewed hope for a vaccine. A Phase 2 proof-of-concept trial of 4CMenB vaccination against gonorrhoea in adults is currently underway.

Objectives

To investigate the potential public health impact of adolescent gonorrhoea vaccination in England, considering different implementation strategies.

Methods

We developed a deterministic transmission-dynamic model of gonorrhoea infection among heterosexual 13-64-year-olds stratified by age, sex and sexual activity. We explored the impact of a National Immunisat

SUBMITTER: Looker KJ 

PROVIDER: S-EPMC9829524 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature