Application of real-time quaking-induced conversion in Creutzfeldt-Jakob disease surveillance.

ABSTRACT:

Background

Evaluation of the application of CSF real-time quaking-induced conversion in Creutzfeldt-Jakob disease surveillance to investigate test accuracy, influencing factors, and associations with disease incidence.

Methods

In a prospective surveillance study, CSF real-time quaking-induced conversion was performed in patients with clinical suspicion of prion disease (2014-2022). Clinically or histochemically characterized patients with sporadic Creutzfeldt-Jakob disease (n = 888) and patients with final diagnosis of non-prion disease (n = 371) were included for accuracy and association studies.

Results

The overall test sensitivity for sporadic Creutzfeldt-Jakob disease was 90% and the specificity 99%. Lower sensitivity was associated with early disease stage (p = 0

SUBMITTER: Hermann P 

PROVIDER: S-EPMC9829526 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature