Serotonin regulation of behavior via large-scale neuromodulation of serotonin receptor networks.

ABSTRACT: Although we understand how serotonin receptors function at the single-cell level, what role different serotonin receptors play in regulating brain-wide activity and, in turn, human behavior, remains unknown. Here, we developed transcriptomic-neuroimaging mapping to characterize brain-wide functional signatures associated with specific serotonin receptors: serotonin receptor networks (SRNs). Probing SRNs with optogenetics-functional magnetic resonance imaging (MRI) and pharmacology in mice, we show that activation of dorsal raphe serotonin neurons differentially modulates the amplitude and functional connectivity of different SRNs, showing that receptors' spatial distributions can confer specificity not only at the local, but also at the brain-wide, network level. In humans, using resting-s

SUBMITTER: Salvan P 

PROVIDER: S-EPMC9829536 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature