Brain, cognitive, and physical disability correlates of decreased quality of life in patients with Huntington's disease.

ABSTRACT:

Purpose

Following a case-control design, as a primary objective, this study aimed to explore the relationship between quality of life (QoL) scores and gray matter (GM) volumes in patients with Huntington's disease (HD). As a secondary objective, we assessed the relationship between QoL scores and other important behavioral, clinical and demographical variables in patients with HD and HD patients' caregivers.

Methods

We recruited 75 participants (25 HD patients, 25 caregivers, and 25 controls) and assessed their QoL using the World Health Organization Quality of Life scale-Brief Version (WHOQOL-BREF). Participants were also assessed with general cognitive functioning tests and clinical scales. In addition, we acquired MRI scans from all participants.

Results

Our result

SUBMITTER: Junca E 

PROVIDER: S-EPMC9829572 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature