Patient-specific identification of genome-wide DNA-methylation differences between intracranial and extracranial melanoma metastases.

ABSTRACT: Melanomas frequently metastasize to distant organs and especially intracranial metastases still represent a major clinical challenge. Epigenetic reprogramming of intracranial metastases is thought to be involved in therapy failure, but so far only little is known about patient-specific DNA-methylation differences between intra- and extracranial melanoma metastases. Hierarchical clustering of the methylomes of 24 patient-matched intra- and extracranial melanoma metastases pairs revealed that intra- and extracranial metastases of individual patients were more similar to each other than to metastases in the same tissue from other patients. Therefore, a personalized analysis of each metastases pair was done by a Hidden Markov Model to classify methylation levels of individual CpGs as decreased

SUBMITTER: Kraft T 

PROVIDER: S-EPMC9829750 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature