Prostaglandin-E₂ levels over the course of glyceryl trinitrate provoked migraine attacks.

ABSTRACT: Administration of glyceryl trinitrate (GTN), a donor of nitric oxide, can induce migraine-like attacks in subjects with migraine. Provocation with GTN typically follows a biphasic pattern; it induces immediate headache in subjects with migraine, as well as in healthy controls, whereafter only subjects with migraine may develop a migraine-like headache several hours later. Interestingly, intravenous infusion with prostaglandin-E₂ (PGE₂) can also provoke a migraine-like headache, but seems to have a more rapid onset compared to GTN. The aim of the study was to shed light on the mechanistic aspect PGE₂ has in migraine attack development. Therefore, PGE₂ plasma levels were measured towards the (pre)ictal state of an attack, which we provoked with GTN

SUBMITTER: Harder AVE 

PROVIDER: S-EPMC9829921 | biostudies-literature | 2023 Jan-Jul

REPOSITORIES: biostudies-literature