Potential diagnostic role of circulating MiRNAs in colorectal cancer.

ABSTRACT:

Objectives

Colorectal cancer (CRC) is the third most common and fourth most deadly cancer worldwide despite its various screening method. Thus, the search for novel and better markers is continuous. This study aimed to assess the combined expression levels of miR-133a, miR-574-3p, and miR-27a in early diagnosis of colorectal cancer in comparison to traditional tumor markers (CEA and CA19.9).

Methods

miR-133a, miR-574-3p, and miR-27a were assessed in sera of 120 participants categorized into healthy control group (n = 20), benign group (n = 30) and malignant group (n = 70) using real-time PCR.

Results

miR-133a, miR-574-3p, and miR-27a expressions showed significant difference among different staging, grading and tumor size of CRC. The sensitivities

SUBMITTER: Abo-Elela DA 

PROVIDER: S-EPMC9830083 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature