Hydrazone modification of non-food natural product sclareolide as potential agents for plant disease.

ABSTRACT: Plant diseases and their drug resistance pose a serious threat to agricultural production. One way to solve this problem is to discover new and efficient botanical pesticides. Herein, a series of novel hydrazide-hydrazone-containing sesquiterpenoid derivatives were synthesized by simply modifying the structure of the non-food natural product sclareolide. The biological activity results illustrated that compared to ningnanmycin (39.2 μg/mL), compound Z28 had the highest antiviral activity against tobacco mosaic virus (TMV), and the concentration for 50% of maximal effect (EC₅₀) of its inactivation activity was 38.7 μg/mL, followed by compound Z14 (40.6 μg/mL). Transmission electron microscopy (TEM) demonstrated that TMVs treated with compounds Z14 and Z28<

SUBMITTER: Dai A 

PROVIDER: S-EPMC9830171 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature