Bioinformatics analysis on the expression of GPX family in gastric cancer and its correlation with the prognosis of gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common cancers of the digestive tract, with the fifth-highest incidence and third highest mortality rate in the world.

Methods

In this study, the Kaplan-Meier Plotter database was used to analyze the correlation between the expression of the glutathione peroxidase (GPX) family and the clinical prognosis of gastric cancer (GC). The prognostic value of increased GPX family mRNA expression in GC patients in different clinical stages, with different differentiation degrees, in different genders and human epidermal growth factor receptor-2 (HER2) status, and treated with different therapeutic regimens was also studied.

Results

The results showed that with the increase of GPX1 and GPX2 mRNA low expression levels, the overall

SUBMITTER: Ye S 

PROVIDER: S-EPMC9830173 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature