LAG3 Regulates T Cell Activation and Plaque Infiltration in Atherosclerotic Mice.

ABSTRACT:

Background

The immune checkpoint receptor lymphocyte-activation gene 3 (LAG3) is a new target for immune checkpoint blockade (ICB), but the effects of LAG3 on atherosclerosis are not known.

Objectives

The aim of the study was to evaluate the role of LAG3 on plaque inflammation using murine hypercholesterolemic models of atherosclerosis.

Methods

To study the role of LAG3 in atherosclerosis, we investigated both bone marrow chimeras lacking LAG3 in hematopoietic cells as well as global Lag3 ^-/- knockout mice. Effects of anti-LAG3 monoclonal antibody monotherapy and combination therapy with anti-programmed cell death protein 1 (PD-1) were tested in hypercholesterolemic low-density lipoprotein receptor knockout (Ldlr ^-/- )

SUBMITTER: Mulholland M 

PROVIDER: S-EPMC9830219 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature