Landscape and clinical impact of metabolic alterations in non-squamous non-small cell lung cancer.

ABSTRACT:

Background

Metabolomics studies to date have described widespread metabolic reprogramming events during the development of non-squamous non-small cell lung cancer (NSCLC). Extending far beyond the Warburg effect, not only is carbohydrate metabolism affected, but also metabolism of amino acids, cofactors, lipids, and nucleotides.

Methods

We evaluated the clinical impact of metabolic reprogramming. We performed comparative analysis of publicly available data on non-squamous NSCLC, to identify concensus altered metabolic pathways. We investigated whether alterations of metabolic genes controlling those consensus metabolic pathways impacted clinical outcome. Using the clinically annotated lung adenocarcinoma (LUAD) cohort from The Cancer Genome Atlas, we surveyed the distributio

SUBMITTER: Ivanina Foureau AV 

PROVIDER: S-EPMC9830272 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature