Role of ctDNA for the detection of minimal residual disease in resected non-small cell lung cancer: a systematic review.

ABSTRACT:

Background

Operable stage I-III non-small cell lung cancer (NSCLC) has a high risk of recurrence, mainly due to remnant clones of the disease defined as minimal residual disease (MRD). Adjuvant chemotherapy has a limited efficacy in reducing the risk of relapse, and prognostic as well as predictive biomarkers in this context are currently missing.

Methods

We performed a systematic review to evaluate the state of the art about the role of circulating tumor DNA detection through liquid biopsy for the assessment of MRD in resected early-stage NSCLC patients.

Results

Among the 650 studies identified, 13 were eligible and included. Although highly heterogeneous, all the studies demonstrated a poor prognosis in patients with post-operative MRD, with a detection rate ranging

SUBMITTER: Verze M 

PROVIDER: S-EPMC9830273 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature