Advanced brain age correlates with greater rumination and less mindfulness in schizophrenia.

ABSTRACT:

Background

Individual variation in brain aging trajectories is linked with several physical and mental health outcomes. Greater stress levels, worry, and rumination correspond with advanced brain age, while other individual characteristics, like mindfulness, may be protective of brain health. Multiple lines of evidence point to advanced brain aging in schizophrenia (i.e., neural age estimate > chronological age). Whether psychological dimensions such as mindfulness, rumination, and perceived stress contribute to brain aging in schizophrenia is unknown.

Methods

We estimated brain age from high-resolution anatomical scans in 54 healthy controls (HC) and 52 individuals with schizophrenia (SZ) and computed the brain predicted age difference (BrainAGE-diff), i.e., the delta betwe

SUBMITTER: Abram SV 

PROVIDER: S-EPMC9830317 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature