Does chemotherapy regimen matter in the neoadjuvant treatment of esophageal cancer?

ABSTRACT:

Background

Neoadjuvant chemoradiotherapy has become the mainstay of treatment for locally advanced esophageal cancer. CALGB 9781 trial established cisplatin and 5-flourouracil (5-Fu) with radiotherapy as superior to surgery alone while the CROSS trial established paclitaxel, carboplatin, and radiotherapy as superior to surgery alone. Previous data has been unclear as to which regimen provides a superior pathologic response. This study aims to look at this. This study aims to look at this.

Methods

A retrospective chart review at a single institution of patients who underwent esophagectomies after neoadjuvant chemoradiotherapy with either cisplatin and 5-Fu or carboplatin and paclitaxel between 2012-2020 was performed. Demographics as well as staging, response rates, and modif

SUBMITTER: Logarajah S 

PROVIDER: S-EPMC9830326 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature