Prognostic value of nicotinamide adenine dinucleotide (NAD⁺) metabolic genes in patients with stomach adenocarcinoma based on bioinformatics analysis.

ABSTRACT:

Background

Because stomach adenocarcinoma (STAD) has a poor prognosis, it is necessary to explore new prognostic genes to stratify patients to guide existing individualized treatments.

Methods

Survival and clinical information, RNA-seq data and mutation data of STAD were acquired from The Cancer Genome Atlas (TCGA) database. Fifty-one nicotinamide adenine dinucleotide (NAD⁺) metabolism-related genes (NMRGs) were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome databases. Differentially expressed NMRGs (DE-NMRGs) between STAD and normal samples were screened, and consistent clustering analysis of STAD patients was performed based on the DE-NMRGs. Survival analysis, Gene Set Enrichment Analysis (GSEA), mutation frequency analysis, immune

SUBMITTER: Cai L 

PROVIDER: S-EPMC9830334 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature