Chemotherapy is associated with improved survival in a national cohort of stage IV pancreatic adenosquamous carcinoma.

ABSTRACT:

Background

Pancreatic adenosquamous carcinoma (PASC) is a rare cancer that often presents with advanced disease and carries a grim prognosis. PASC is defined by the presence of at least 30% malignant squamous cells in the presence of malignant ductal adenocarcinoma. The utility of chemotherapy in the setting of metastatic disease is unknown.

Methods

In this cross-sectional analysis, patients with stage IV PASC diagnosed between 2006 and 2016 were abstracted from the National Cancer Data Base. Patients were then categorized according to whether they received chemotherapy. Multivariable logistic regression analysis was done to determine the odds of receiving palliative chemotherapy. Overall survival analysis was performed using Kaplan-Meier analysis. A Cox proportional hazard

SUBMITTER: Altshuler E 

PROVIDER: S-EPMC9830350 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature