Childhood body mass index trajectories, adult-onset type 2 diabetes, and obesity-related cancers.

ABSTRACT:

Background

Elevated childhood body mass index (BMI), commonly examined as a "once-only" value, increases the risk of cancer and type 2 diabetes (T2D) in adulthood. Continuous exposure to adiposity during childhood may further increase cancer risk. We examined whether longitudinal childhood BMI trajectories were associated with adult obesity-related cancer and the role of adult-onset T2D in these associations.

Methods

Five sex-specific latent class BMI trajectories were generated for 301 927 children (149 325 girls) aged 6-15 years from the Copenhagen School Health Records Register. Information on obesity-related cancers and T2D was obtained from national health registers. Incidence rate ratios (IRR), cumulative incidences, and confidence intervals (CI) were estimated using P

SUBMITTER: Jensen BW 

PROVIDER: S-EPMC9830482 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature