Ghrelin Predicts Stimulant and Sedative Effects of Alcohol in Heavy Drinkers.

ABSTRACT:

Aim

The aim of this study was to examine the relationship between ghrelin levels and the subjective effects of alcohol in heavy drinkers, and to compare them to healthy controls.

Methods

Ghrelin levels were collected as part of two laboratory studies. Both groups received either IV infusion of saline or high dose of alcohol (100 mg%). In the study of heavy drinkers, ghrelin was gathered on all subjects, but data was analyzed only for participants who received placebo (N=12). Healthy controls (N=20) came from another study that collected data on family history. Ghrelin levels and measures of alcohol effects (BAES, VAS, NDS, YCS [see manuscript for details]) were collected at 4 timepoints: baseline, before infusion, during infusion and after infusion.

Results

IV alcohol

SUBMITTER: Ralevski E 

PROVIDER: S-EPMC9830489 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature