Novel Role of the SIRT1 in Endocrine and Metabolic Diseases.

ABSTRACT: Silent information regulator 1 (SIRT1), a highly conserved NAD⁺-dependent deacetylase, is a cellular regulator that has received extensive attention in recent years and regarded as a sensor of cellular energy and metabolism. The accumulated evidence suggests that SIRT1 is involved in the development of endocrine and metabolic diseases. In a variety of organisms, SIRT1 regulates gene expression through the deacetylation of histone, transcription factors, and lysine residues of other modified proteins including several metabolic and endocrine signal transcription factors, thereby enhancing the therapeutic effects of endocrine and metabolic diseases. These evidences indicate that targeting SIRT1 has promising applications in the treatment of endocrine and metabolic diseases. This r

SUBMITTER: Lu C 

PROVIDER: S-EPMC9830516 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature