Statin contribution to middle cerebral artery blood flow velocity in older adults at risk for dementia.

ABSTRACT:

Purpose

It is plausible that statins could improve cerebral blood flow through pleiotropic mechanisms. The purpose of this investigation was to assess the contribution of statins to cerebrovascular variables in older adults with dyslipidemia and familial history of dementia. Furthermore, we explored the interaction between statin use and sex due to prevalent bias in statin trials.

Methods

Middle cerebral artery blood flow velocity (MCAv) was measured using transcranial Doppler ultrasound. Continuous supine rest recordings lasted 8 min. Participants included in analyses were statin (n = 100) or non-statin users (n = 112).

Results

MCAv and cerebrovascular conductance were significantly higher in statin users (p = 0.047; p = 0.04), and pulsatility index (PI) was signific

SUBMITTER: Aaron SE 

PROVIDER: S-EPMC9830632 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature