Nontargeted metabolomics reveals the potential mechanism underlying the association between birthweight and metabolic disturbances.

ABSTRACT:

Aims

The aim of this study was to characterize the metabolites associated with small- and large-gestational-age newborns in maternal and cord blood, and to investigate potential mechanisms underlying the association between birthweight and metabolic disturbances.

Research design and methods

We recorded detailed anthropometric data of mother-offspring dyads. Untargeted metabolomic assays were performed on 67 pairs of cord blood and maternal fasting plasma samples including 16 pairs of small-for-gestational (SGA, < 10th percentile) dyads, 28 pairs of appropriate-for-gestational (AGA, approximate 50 percentile) dyads, and 23 pairs of large-for-gestational (LGA, > 90th percentile) dyads. The association of metabolites with newborn birthweight was conducted to screen for metaboli

SUBMITTER: Zhai X 

PROVIDER: S-EPMC9830726 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature