Unique genetic variants of lean nonalcoholic fatty liver disease: a retrospective cohort study.

ABSTRACT: We investigated the prevalence and clinical metabolic characteristics of lean nonalcoholic fatty liver disease (NAFLD) in an elderly Chinese population and assessed the relevance of lipid markers and genetic variation. All 5,338 community subjects underwent detailed clinical and laboratory examinations and were divided into three groups: lean (Body mass index (BMI) < 23 kg/m², n = 2,012), overweight (BMI = 23-24.9 kg/m², n = 1,354), and obese (BMI ≥ 25 kg/m², n = 1,972). Single nucleotide polymorphisms were selected based on those reported in previous NAFLD or obesity genome-wide association studies. The frequencies of alleles and genotypes were calculated and statistically analyzed with Pearson's χ² tests. One-way ANCOVA was used to test the ass

SUBMITTER: Li J 

PROVIDER: S-EPMC9830772 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature